IB Neuro™

Dynamic susceptibility contrast (DSC) MRI methods that allow the creation of relative cerebral blood volume (rCBV) maps have the potential to provide more specific information about brain tumor biology and vasculature than compared to standard anatomical MR images.  Several laboratories have demonstrated the feasibility of determining rCBV in patients with brain tumors. It has been shown that MRI-derived rCBV may:  1) better differentiate histologic brain tumor types than conventional MRI; 2) provide information to predict glial tumor grade; and 3) may even predict survival better than conventional histopathological tumor grading.  In addition, rCBV maps may aid in the differentiation of post-treatment changes from tumor recurrence, and predict local recurrence or malignant transformation earlier than conventional anatomical MR imaging.

IB Neuro™ provides a significant leap in magnetic resonance (MR) perfusion analysis. The technology is based on over 20 years of award winning research. During that time, more than 4,000 perfusion studies were performed in patients with brain tumors under institutional review board (IRB) approved protocols.  IB Neuro™ analyzes dynamically acquired MR datasets and generates parametric maps of the brain that include relative cerebral blood volume (rCBV), blood flow (CBF), Tmax, and mean transit time (MTT).  IB Neuro™ software is currently available for the aycan workstation OsiriXPRO and OsiriX applications.  IB Neuro is compliant with healthcare standards such as DICOM and easily integrates into existing medical image visualization systems. 


  • Platform-independent library allows for seamless integration into existing server and workstation applications.

  • Instantaneously computes and displays a complete set of perfusion maps from dynamic susceptibility contrast

  • MR imaging data using push-button processing including; rCBV, CBF, MTT, TTP, and Tmax

  • Automatically corrects for artifacts in rCBV maps caused by contrast agent leakage across disruptions in the blood brain barrier

  • Displays the dynamic MR signal time course for any chosen brain location

  • Automatically exports perfusion parameter maps to the same medical imaging examination in DICOM compatible format

  • Automatically generates a report with summary statistics

  • Integrates with multiple PACS to assess data and distribute results

  • Normalizes perfusion parameters to Normal Appearing White Matter (NAWM) to facilitate comparisons across serial imaging studies in the same patient, and comparisons between patients

  • Automated selection of arterial input functions (AIFs) for CBF

  • CT Perfusion post-processing

  • Longitudinal reporting capability

  • Ability to output maps fused to anatomical with registration